将编码受体跨膜和胞质区段的突变人类cDNA插入小鼠基因组序列中。这种变异导致了两个多功能酪氨酸酶模激活位点Y1349VHVNATY1356VNV的改变,变为Y1349EEINATY1356EEI。构建中包含的 floxed neo标记通过与Cre敲除小鼠杂交被剔除。(来源:J:94030)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
核苷酸替换
--
1
11
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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