将编码受体跨膜和胞质区段的突变人类cDNA插入小鼠基因组序列中。这种变异导致了两个多功能酪氨酸酶模激活位点Y1349VHVNATY1356VNV的改变,变为Y1349EEINATY1356EEI。构建中包含的 floxed neo标记通过与Cre敲除小鼠杂交被剔除。(来源:J:94030)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count