将编码受体跨膜和胞质区段的突变人类cDNA插入小鼠基因组中,导致两个多功能酪氨酸酶模激活位点Y1349VHVNATY1356VNV变为了Y1349MDMSATY1356MDMS。构建中包含的floxed neo通过与Cre敲除小鼠杂交被剔除。(来源:J:94030)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count