转基因中包含大鼠probasin启动子、小鼠Cdc37开放阅读框以及SV40标签剪接位点/polyadenylation信号序列。转基因插入位点推测位于Y染色体,因为所有转基因小鼠均为雄性。转基因小鼠在前列腺上皮中过表达Cdc37,这是内源性Cdc37基因产物缺失或表达水平低的组织(来源:J:93695)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x DBA/2)F1
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插入
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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