设计了一种靶向载体,用于替换mu3B在exon 2下游的ATG位置,插入了EGFP和一个含floxed neo的序列。Cre表达后,neo被剔除了。RT-PCR结果显示突变大脑和脊髓中无转录本。EGFP在大脑的神经元中普遍存在。(来源:J:93312)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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