第六外显子编码高亲和力的DNA结合域,通过同源重组,用一个包含PGK-neo和胸腺嘧啶激酶选择标记的构建进行同源插入,使得LoxP序列环绕。随后,通过将靶向的ES细胞转染含Cre表达质粒,短暂转染去除了PGK-neo-thymidine kinase标记,使得第六外显子两侧留有LoxP位点。(来源:J:93481)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count