这个转基因包含一个0.4千碱基的DNA片段,包含了小鼠晶状体α1基因的启动子,驱动表达的是小鼠眼睑相关homeobox 3同源蛋白(Drosophila的Six3)的完整全长1.4千碱基的cDNA。之后是SV40内含子和polyadenylation信号。转基因mRNA在胚胎期12日(E12.0)就能检测到,发育期间(E12.0-E13.5)仅在晶状体纤维细胞中表达,并且空间上与内源性Pax6的表达有重叠。(来源:J:77351)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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