Plekhb1^tm1Dva

Beta-gal and a neomycin resistance gene were inserted into exon 3 following codon 22, thereby disrupting all four isoforms of the endogenous gene. Staining for Beta-gal showed intense expression of the mutant allele in photoreceptors and in some cells of the retinal ganglion cell layer, consistent with normal endogenous expression. (J:93317)