将鸽子的cytochrome c基因工程改造,以便在转基因小鼠的淋巴组织中以两种形式表达。这种构建中的cytochrome c在细胞质合成后定向到线粒体(称为ePCC)。在携带这种转基因的小鼠中,mRNA表达水平低于携带Tg(H2KmPCC)2939的小鼠。实验在胸腺、脾脏和经LPS刺激的B细胞中通过Northern blot检测到PCC的表达。(来源:J:92997)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6 x SJL
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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