在3' UTR中插入了IRES-cre cassette和FRT引导的neo序列。与FLP剔除小鼠杂交后,neo被剔除。免疫染色结果显示,插入的序列不影响内源性表达,并且cre在突变性中脑和肾上腺中表达。cre的表达也在卵母细胞中检测到。(来源:J:93194)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入
--
1
2
98

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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