在3' UTR中插入了IRES-cre cassette和FRT引导的neo序列。与FLP剔除小鼠杂交后,neo被剔除。免疫染色结果显示,插入的序列不影响内源性表达,并且cre在突变性中脑和肾上腺中表达。cre的表达也在卵母细胞中检测到。(来源:J:93194)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count