设计了一种靶向载体,用AA替换内源性位点的六肽序列中的WM残基。与普遍表达的Cre小鼠杂交后,去除了由载体引入的floxed neo。该蛋白的表达量和稳定性没有改变。(来源:J:93020)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv
Targeted
核苷酸替换
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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