这个转基因包含了人类的CD8α和β链基因,由T细胞特异性的Lck启动子驱动。在胸腺细胞中,62%表达为CD8α-α同源二聚体,14%为CD8α-β异二聚体。在外周T细胞中,CD8α-β异二聚体以4:1的比例更偏好表达。人类CD8α在CD4+和CD8+的T细胞上都有检测到。(来源:J:92994)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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插入
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2
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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