Tnnt2^tm1Mmto

A floxed neo cassette was inserted between exons 12 and 13 and an exon 13 containing a deletion of three base pairs that results in the deletion of lysine at position 210 (K210) were inserted via homologous recombination. Immunohistochemical and western blot analysis indicate absence of protein expression in hearts from homozygous mice. (J:141967)