一个新霉素抗性基因座替换了基因的33-39号外显子。这个替换去除了δ亚基和α-2亚基的87个C端氨基酸。北半球脑组织的Northern印迹检测到了剪切的5' mRNA,但未检测到3'区域。从脑组织提取的RT-PCR没有检测到目标的3'转录本区域。(来源:J:92396)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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