Tg(Myl1-Prkag3*R225Q)1Sson

A Myl1 promoter and enhancer drive expression of a full length mouse Prkag3 cDNA with a single missense mutation (R225Q). Expression of the mutated protein was seen in the skeletal muscle. Levels of the endogenous PRKAG3 protein were reduced resulting in no significant change in overall PRKAG3 protein expression. (J:92821)