Exon 1,包含Pparg1同源异构体的起始翻译位点,以及部分Exon 2,编码DNA结合域的第一个锌指,被替换了PGK-neo cassette。这种事件导致了这两种isoform 1和2的中断,因为在白色脂肪组织的Western blot中检测不到蛋白质(来源:J:92826)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
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1
10
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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