在exon 2的ATG后面插入了lacZ-PGK-neo cassette,替换了整个exon 2。PCR分析证实了纯合小鼠中野生型转录本的缺失。染色结果显示lacZ在脂肪细胞、心肌细胞、骨骼肌细胞和平滑肌细胞中存在。(来源:J:92922, J:121109)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入
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1
--
23

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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