在exon 1的起始位置插入了eGFP和含floxed neo的序列,这导致了exon 1的大部分和exon 2完全被删除,从而消除了约80%的开放阅读框,包括homeodomain。通过与表达Cre的生殖细胞特异性小鼠杂交,floxed neo被去除了。PCR结果显示突变小鼠中确实发生了重组。(来源:J:91405)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/SvImJ
Targeted
插入,基因内删除
--
1
--
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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