将内含原生启动子和增强子序列的重排TCRα和β基因注入1细胞胚胎的微核中。这两个构建物特异性针对鸽子血红蛋白c的羧基端片段和Ek分子。这种转基因TCRα链在氨基酸99的位置有一个差异(阿尔法氨基酸替换为丝氨酸,而非Thr,而非Tg(TcraTcrbAD10)1Hed转基因小鼠中表达的同源α链)。(来源:J:85777)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F2
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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