插入了带有博泰戈基因剪接 cassette 的元件到内皮2号染色体。PCR结果显示小鼠中发生了重组。北印迹实验显示转录被阻断,而 Western 印迹则证实了突变体大脑中完全没有蛋白质(来源:J:92302)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
插入
--
1
10
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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