Tg(Apoa2)1Lus

The transgene contains mouse apolipoprotein A-II sequence from Swiss 3T3 cells with 4.5 kb of upstream sequence and 8.5 kb of downstream sequence. About 10 copies of the transgene integrated into the genome. The apoA-II expressed from the Swiss 3T3 cell genomic clone carries a more basic apoA-II allele (found among many inbred strains of mice) than the C57BL/6J apoA-II allele. Expression of the transgene in the liver was 4-fold higher than endogenous gene expression. (J:92454)