在突变小鼠的5' UTR的exon 1区域插入了GFPneo。Southern印迹和PCR确认了重组。RT-PCR结果显示,突变体中没有转录本,而telomerase重复扩增(TRAP)试验显示,来自突变体睾丸细胞提取物中没有telomerase活性。(来源:J:92243)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
21
18

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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