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中文
设计了一个靶向载体，用于替换编码180-255位氨基酸的7-9号外显子，替换为一个拼接接受器和IRE-SB-neo-pA插件，以干扰DNA解旋酶二域。Southern blot在ES细胞中证实了重组，而突变胚胎的Northern blot未检测到基因3'端的转录本。正如预期的那样，突变胚胎中LacZ表达正常。（来源：J:91351）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
