将Myh10tm3Rsad小鼠与携带Cre基因的生殖细胞杂交,产生了这种突变,其中删除了floxed neo,保留了exon 17上游的单个LoxP位点以及exon 17的R709C突变。 Western blot结果显示,突变大脑中这种等位基因的表达恢复到了野生型水平。(来源:J:92081)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
核苷酸替换
--
1
5
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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