Exon 2被一种人类cDNA的突变形式替换,其中Lys833被Arg替换,接着是带有loxP序列的诺福克林抗性基因(Neor)座。杂合子小鼠与平衡Cre小鼠杂交,以删除Neor座。逆转录PCR显示了突变mRNA的特异性产生。(来源:J:91945)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
Insertion, Nucleotide substitutions
--
1
1
40

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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