将含有三个GAL4结合位点(UAS)和一个带有floxed ura3和neomycin抗性基因座的靶向构建插入到了CTCF位点下游的DMR区域。短暂的Cre表达剪切掉了ura3和neo基因座。敲入操作并未干扰H19的非编码RNA表达。(来源:J:91713)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
插入
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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