将Pax8tm1(cre)Mbu与小鼠杂交,这些小鼠在生殖细胞中表达FLP重组酶,产生了这种突变,其中插入Cre的Frt-flankedneo序列被剔除了,从而允许Cre的表达。Cre重组酶在已知的Pax8表达区域检测到了表达,同时在肾上腺、面神经、前庭耳蜗和楔束神经中也发现了表达。(来源:J:89762)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
5
41

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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