在exon 1和包括2-4号外显子共4kb的序列中,编码序列被替换成了带有floxed Dsred-FRT-puro-pA元件、Pax7的cDNA以及一个FRT标记的IRESnlacZ cassette。剪接供体位点被消除,以防止产生功能性的Pax3蛋白。Southern blot实验证实了重组的发生。(来源:J:90568)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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