这个转基因包含了野生型人乳头瘤病毒16(HPV16)的整个早期编码序列,从nt97到nt6152。它被大约2千碱基的DNA片段簇拥,包括人角蛋白14(Epidermolysis Bullosa Simplex, Dowling-Meara, Koebner)基因的启动子/增强子,下游接着是该基因3'端非翻译区500个碱基,包括其polyadenylation信号。角蛋白14的启动子驱动在鳞状上皮基底细胞中的转基因表达。(来源:J:20125)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x DBA/2)F2
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50

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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