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中文
这个等位基因是通过靶向载体构建的，它替换并打断了编码催化区域（catlytic domain）的1-5号外显子，然后插入了一个含有LacZ（乳糖操纵子-z）和核定位信号的基因。PGK-gpt/neomycin抗性基因座反向插入在LacZ下游。对纯合突变纤维细胞的Northern blot分析未检测到mRNA，而突变胚胎的Western blot也证实了无蛋白表达（来源：J:91198, J:158339）。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
