Fxr1htm1.1Dln小鼠与CAG-Cre表达的鼠杂交后,产生了在启动子和exon 1位置有一个单个loxp点的突变基因。 Western blot结果显示,这些突变小鼠的心脏、肌肉和大脑中没有检测到蛋白质。(来源:J:91191)
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Fxr1htm1.1Dln mice were crossed with CAG-Cre expressing mice, resulting in an allele with a single loxp site in the place of the promoter and exon 1. Western blot analysis indicated lack of protein in mutant heart, muscle, and brain. (J:91191)