Fxr1^tm1Dln

A floxed neo was inserted upstream of exon 2, and an additional loxP site inserted upstream of the promotor. Western blot shows reduced levels of the 82 and 84 kDa isoforms in cardiac and skeletal muscles and smaller isoforms in brains relative to wild type animals, indicating possible alterations in alternative splicing patterns, and that this allele is putatively hypomorphic. (J:91191)