Fmn1^tm1.1Zllr

This allele was generated from Fmn1tm1Zlr by crossing to Tg(CMV-cre)1Cgn mice. Cre expression causes the excision of 170 kb containing the remaining exons between 9 and 24; the hygro cassette is also deleted. The predicted protein product is similar to that of Fmn1tm1Zlr in that the translation is out-of-frame after exon 9. In addition, transcription of Grem1 is disrupted owing to the deletion of a Grem1 regulatory region in an Fmn1 intron. (J:91385)