Cre介导的Rfx3tm1Wrth基因的重组导致了3号外显子的剔除,留下了一个由FRT序列标记的neo插入。3号外显子编码DNA结合区域。RT-PCR结果显示,3号外显子的缺失导致了2号外显子与4号外显子的拼接,产生了一个框架突变,并在无框架的终止密码子处提前终止。(来源:J:89880)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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