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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Rr27
tm2Rohl
Alias:
H19
tm2Rohl
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基础信息
表型特征
文献报道
在 imprinting 控制区 (ICR) 中的 CTCF 目标位点 4 从一个中央的 GTGG 序列被改造成了 ATAT,通过同源重组。包含在导向载体中的一个 floxed 非抗药性 neo 氨基酸基因座通过体内 Cre 介导的重组在生殖细胞中被剔除。Southern blot 分析和序列分析确认了这一重组事件。(来源:J:89915)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3045724
Not Specified
Targeted
Insertion, Nucleotide substitutions
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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