在exon 1的3'位置插入了带有FRT标记的neo基因和一个单个的loxP序列,而在exon 1的5'端则插入了一个倒位的loxP位点。通过Southern blot对突变的ES细胞进行了检测,确认了重组的发生。(来源:J:90393)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJaeSor
Targeted
插入
--
1
11
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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