Abcb1a^mds

The analysis of the genomic locus revealed an insertion of a solo long terminal repeat (LTR) of the ecotropic murine leukemia virus in the reverse orientation in the intron of the mdr-3 gene, causing abnormal splicing and thereby disrupting the mdr-3 gene function. This allele is also present in strains SAMP1, SAMP6, SAMP7, SAMP9, SAMR1, SAMR4 and SAMR5. The identical mutation is found in Crl:CF1 mice. (J:64725, J:208754)