Cre介导的重组去除了Hip1tm2Tsr基因的3-5号含floxed外显子和neo cassette,通过对突变大脑的 Western blot 检测证实了没有蛋白表达。表型分析表明,这种等位基因可能是隐性的。(来源:J:90400)
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Cre-mediated recombination excised floxed exons 3-5 and the neo cassette in Hip1tm2Tsr. Western blot analysis of mutant brains confirmed absence of protein. Phenotypic analysis suggests that this allele may be a hypomorph. (J:90400)