在exon 2的终止密码子之后立即插入了一个包含IRES-lacZ和neo的磁带。虽然北印迹分析检测不到,但RT-PCR分析识别出了转录本,表明在纯合突变小鼠中,信使RNA的量相对于野生型显著减少。插入的lacZ基因被表达出来了。(来源:J:89907)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
27
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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