将小鼠Mecp2的编码序列、修改后的Kozak序列和新插入的neo-cassette通过同源重组插入Mapt的exon 1中。产生的融合蛋白包含Mapt的前31个氨基酸和Mecp2,主要在大脑(包括成熟神经元)、肺和肾中高表达。(来源:J:89593)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
14
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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