一段包括起始密码子ATG的exon 1被替换为包含内切位点、tau-GFP融合基因、loxP、PGK-1启动子、诺卡因抗性基因、PGK-1polyA尾巴以及第二个loxP位点的 cassette。 Western blot结果显示,纯合无基因突变小鼠的脊髓中未检测到蛋白质。tau-GFP融合蛋白由Robo3启动子驱动表达。(来源:J:89438)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
1
25

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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