新构建的neo cassette替换了包含完整5' UTR、起始密码子、信号肽以及首个LNS域的首个exon。在突变小鼠的 Western blot 分析中未检测到该蛋白(来源:J:45298)。
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A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Protein was undetected by Western blot analysis of mutant mice. (J:45298)