通过在第六外显子3'端插入一个由Loxp座 flank的neo cassette,生成了一个全局性功能减弱的Arnt等位基因。这个neo cassette后面跟着一个5'端的Loxp座。 Western blot结果显示,纯合小鼠所有组织中Arnt的表达量均显著降低。(来源:J:89470)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入
--
1
--
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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