将Cre重组酶连接到了Col1a1基因启动子的2.3kb区域。Col1a1的内源性启动子在成骨细胞分化过程中始终活跃,因此检测到Cre重组酶的表达仅限于骨骼中。细胞遗传学定位显示,转基因整合到了14qE2-4染色体上。(来源:J:77071, J:165282)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count