通过Cre介导的重组,去除了Trp53tm3Tyj中LoxP位点附近的STOP cassette,使得在exon 8中表达p.R270H的错义突变。定量RT-PCR结果显示,这个点突变等位基因的表达水平与野生型相当。(来源:J:126915)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
核苷酸替换
--
1
65
21

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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