经过修改的鼠Dll1基因cDNA,编码一个部分缺失了细胞内域的截短蛋白,被连接到了1.2kb的鼠Mesp2启动子后面。构建还包括了SV40的3' UTR和polyA信号。Mesp2启动子预期能驱动在前体体节的中胚层(大约对应于体节S-I)中表达这种突变的Dll1 cDNA。这种突变蛋白将失去141个C端残基,仅剩下靠近跨膜域的12个细胞内残基。(来源:J:88580)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(BALB/c x C57BL/6)F1
--
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部