内源性编码区域被替换为包含佛立翼因(Floxed Sox3)序列、GFP以及frt框引导的neo的构造。佛立翼因通过小鼠野生型中内源性Sox3表达模式一致的Cre介导重组在生殖细胞中去除,使得GFP位于原内源性启动子下游。突变型XY胚胎在模式上表达GFP,但不表达Sox3。这个突变等位基因来源于Sox3tm2Rlb(J:88507)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
其他
--
1
6
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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