编码PDZ1区域的一个外显子被诺瓦克抗性基因 cassette 的插入所打断。通过分析野生型小鼠大脑匀浆的 Western blot,未检测到该蛋白质。(来源:J:88266)
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An exon encoding the PDZ1 domain was disrupted by the insertion of a neomycin cassette. Protein was undetected by Western blot analysis of whole brain lysates obtained from homozygous mice. (J:88266)