在第2外显子的起始密码子处插入了lacZ基因,并紧随其后是一个被敲除的PGK-抗药性基因,这样就完全替换了第2外显子。实验中,异种杂交产生了带有Cre表达特性的转基因小鼠,导致敲除掉了含荧光素的抗药性基因。这种情况下,β-半乳糖苷酶从这个等位基因中表达出来。(来源:J:88168)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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