在插入lacZ和neo基因 cassette 的起始密码子处,前86个碱基的外显子1编码区域被替换。剩下的外显子1和下游序列保持不变。通过免疫荧光,没有在纯合突变视网膜组织中检测到蛋白质。lacZ的表达通过β-半乳糖苷酶染色可见。(来源:J:88182)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
3
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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