设计了一个靶向构建,用于在βactin基因3'非翻译区下游55bp的位置插入一段序列,包含IRES、floxed neo和SV40早期区段。SV40早期区段编码的大T、小t和17kT。插入的元件保留了内源编码序列和引导细胞定位的54bp'zipcode'。表达依赖于floxed neo cassette的去除(在无Cre表达的情况下,这发生频率较低)。(来源:J:87544)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
6
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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